Molecular insight of DREAM and presenilin 1 C‐terminal fragment interactions
نویسندگان
چکیده
منابع مشابه
Molecular cloning and sequencing of rabbit presenilin-1 cDNA fragment.
Molecular cloning and sequencing of a cDNA encoding rabbit presenilin-1 (Ps1) fragment was performed by reverse transcription polymerase chain reaction (RT-PCR) using primers: 5'-GGA TGA GCA GCT AAT CTA TAC C-3' and 5'-TCC ATT CAG GGA GGT ACT TGA TA-3'. The cDNA fragment revealed 402 nucleotides. The sequence was well conserved and found to be 91, 90, 88, 87 and 78% homologous to that of human,...
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Mutations in PSEN1 and PSEN2 genes, encoding presenilin 1 (PS1) and presenilin 2 (PS2), respectively, cause autosomal-dominant Alzheimer’s disease (ADAD) (1, 2). The precise mechanism by which PS1 mutations lead to AD is under active investigation. Multiple theories have been suggested to explain the role of PS1 and PS2 mutations on AD pathogenesis, including the effects on γ-secretase activity...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2016
ISSN: 0014-5793,1873-3468
DOI: 10.1002/1873-3468.12156